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Dr. David Karli on Supplements

I have used and been interested in supplements for as long as I can remember in my adult life. Over the years, as I tried countless brands, pills, capsules and powders, I found myself asking similar questions to most people:

  • How do I know which brand is the best?
  • Is what is on the label actually in the supplement? How do I know?
  • Am I actually absorbing the supplement and not wasting my money?
  • Which supplements should I take?

  • After getting similar questions from so many patients repeatedly, I decided to get more serious about researching supplements and the supplement industry a number of years ago.

    As with most things, what I found was both good and bad.

    First, the good:
    Why Supplements?
  • It has become increasingly accepted that over time the level of nutrients (what is termed nutrient density) of our Western diet has decreased slowly but progressively. What this means is that even with reasonably good food choices and best efforts, we still may not be getting the nutrients we need to maintain optimal health.
  • This raises the obvious opportunity to “supplement” our foods with additional sources to fill in the gaps.
  • Increasingly, we are able to measure nutritional levels in blood tests, to more objectively and specifically define what we most need to support our diets. Nutrigenomics is an emerging area of science where we are able to define what foods our body needs most based on our individual DNA profile.
  • All of this will lead to increasing opportunity to optimize our nutrition to keep our cells as healthy as possible.
  • As it pertains to the cell therapies that we specialize in here at the Karli Center: It is only logical to conclude that the better our general cellular nutrition and health, the more we support the cells we use to treat orthopedic problems!

Now the bad:
What's in the Bottle?
  • Despite steady growth in a vitamin and supplement industry estimated to be greater than $40 billion in 2022, the oversight on quality control of products sold to consumers is modest at best.
  • That means that companies can get products into the market with no proof that what is on the product label is consistently in the product AND that the ingredients in the product are pure, safe and bioavailable (meaning you actually absorb them).
  • This was very similar to my impression of the cell therapy space, which led to me starting a biotech Company to ensure more quality control production of the therapies that we employ at the Karli Center. Finding myself in familiar territory, I set out to get some solutions!
  • The best supplement companies voluntarily undergo independent 3rd party audits at significant expense, meaning an outside company routinely tests their products to make sure that what is on the label is consistently in the products. They also follow standards for good manufacturing processes to ensure safety and have designated research teams to maximize the bioavailability of their product ingredients to ensure absorption.

    Self Renew Supplement Line
    So Which Brand of Products Should I Take?
  • As I researched, without a clear answer to the above questions, it became clear that I wanted better control over the ingredients and the quality of supplements that I was taking and that I would recommend to patients.
  • To do that, my wife (Zoe) and I sought out experts in the field and manufacturing partners to produce a line of supplements that we trusted to be of the highest quality, purity and bioavailability.
  • When asked, I can now say what brand I would recommend and that I take personally.
  • The daily product combination has been created to be as simple and cost effective to produce sound foundational support to our diets and the greatest contribution to the general health of most adults, especially those of us dealing with orthopedic problems and the chronic unhealthy inflammation they create.
  • Check out the video introduction of the products below to learn more.

Are you ready to take the greatest stride toward joint self-renewal?

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